cAMP/PKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes
نویسندگان
چکیده
As you can see from their comments, while referee #1 is rather negative towards your study, referees #2 and #3 are very supportive of its publication and agree on the high potential interest of your findings. In general, although they believe that the evidence presented properly supports your conclusions, some technical concerns have arisen with which you will have to deal before your manuscript is ready for publication. As referee reports are quite explicit I will not repeat their arguments here, but I would like to draw your attention to points 1 and 6 from referee #2 -regarding Lats phosphorylation site and the role of NF2 respectivelyand major point 1 from referee #3 -on the effects of PKA on Lats activityas important concerns that need to be adequately addressed.
منابع مشابه
cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.
Actin cytoskeletal damage induces inactivation of the oncoprotein YAP (Yes-associated protein). It is known that the serine/threonine kinase LATS (large tumour suppressor) inactivates YAP by phosphorylating its Ser127 and Ser381 residues. However, the events downstream of actin cytoskeletal changes that are involved in the regulation of the LATS-YAP pathway and the mechanism by which LATS diffe...
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